BASIC MECHANISMS OF SEIZURES

  • Ferrendelli, James A, (PI)
  • Goldring, Sidney (PI)
  • Collins, Robert (PI)
  • Rothman, Steven (PI)
  • Covey, Douglas (PI)
  • Isenberg, Keith (PI)
  • Miller, John (PI)
  • Toga, Arthur (PI)

Project: Research projectSpecialized Center, Research Program Projects

Description

This is a proposal to continue our program project entitled "Basic
Mechanisms of Seizures". This application describes a program which
represents a major change in direction and emphasis in our research.
Recent studies in our laboratories have led to the discovery of a new class
of neuroactive chemicals -- alkyl substituted gamma- and
thiobutyrolactones. These compounds appear to have novel mechanisms of
action by which they can regulate neuronal excitability in brain. We
believe that neuroactive butyrolactone and related chemical compounds have
great potential diseases and disorders. Because of this we wish to mount a
major research effort to learn more about these compounds and their
molecular and cellular mechanisms and sites of action. The present program consists of four component projects and an
administrative core. The major goals of the component projects are: (1)
to study the chemistry of neuroactive butyrolactones and chemically related
compounds: (2) to characterize the neurologic effects molecular mechanisms
and sites of action of these agents: (3) to define cellular mechanisms of
neuroactive butyrolactones and chemically related compounds and
characterize some of the mechanisms of inhibitory neurotransmission in
mammalian nervous tissue: (4) to define the functional anatomy responsible
for the neurologic effects of the above chemicals and for the expression of
seizures. Our present program brings together a group of talented and productive
medical scientists. Each of the principal investigators has a special find
of knowledge and research skills which make him particularly suited to
carry out our research goals. They have already demonstrated that they
work well together and direct closely interrelated and complementary
research projects. Our project should provide substantial information that will improve our
knowledge of both normal and abnormal brain function and should lead to a
greater understanding and improved treatment of nervous system diseases.
StatusFinished
Effective start/end date1/1/796/30/02

Funding

  • National Institutes of Health: $848,553.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $819,295.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $691,974.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $747,855.00

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Neuropharmacology
Seizures
Nervous System
GABA-A Receptors
Ionophores
Brain
Chlorides
Nervous System Diseases
Research
Convulsants
Anticonvulsants
Pharmaceutical Preparations
Anatomy
Epilepsy
Anti-Anxiety Agents
Molecular Biology
Barbiturates
Hypnotics and Sedatives
Nerve Tissue
Structure-Activity Relationship

Keywords

  • Medicine(all)
  • Neuroscience(all)