BIOCHEMISTRY AND PHARMACOLOGY OF THE RETINA

  • Ferrendelli, James A, (PI)
  • Cohen, Adolph (PI)
  • Blazynski, Christine (PI)

Project: Research projectResearch Project

Description

The investigations proposed deal with three classes of putative
transmitters and or neuromodulators in mammalian retinas and are
concerned with characterizing their distributions, receptors,
influences on cyclic AMP levels in target neurons, possible
interactions between systems utilizing these molecules, and gaining
clues as to their physiological significance. The first of these
is adenosine, which we have found to influence cyclic AMP levels
in the rabbit retina and to be taken up by specific neurons in the
rabbit and mouse retinas. The second class is indoleamines. We
have found in long inbred strains of mice that tryptamine or
serotonin but not melatonin prevents the accumulation of a light-
sensitive pool of cyclic AMP in what our evidence suggests to be
photoreceptors. In addition, it has been reported that long inbred
mouse lines but not mouse lines recently inbred from wild strains
appear to lack pineal melatonin and enzymes involved in its
biosynthesis. Unless regulatory genes are involved, this may also
hold for their retinas, and an opportunity may be at hand to help
define the role of melatonin in mammalian retinas. The third class
of transmitter/modulators is dopamine, which when applied to mouse
retinas in micromolar concentrations, appears to counter the above
effects of tryptamine or light on a light-sensitive pool of cyclic
AMP. Adenosine is also reported to interact with dopamine release.
StatusFinished
Effective start/end date2/1/7812/31/92

Funding

  • National Institutes of Health

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Biochemistry
Retina
Pharmacology
Cyclic Nucleotides
Cyclic AMP
Guanylate Cyclase
Cyclic GMP
Phosphoric Diester Hydrolases
Adenylyl Cyclases
Protein Kinases
Neurotransmitter Agents
Ions
Light

Keywords

  • Medicine(all)