INTESTINAL PROPULSION

  • Weems, William A, (PI)

Project: Research projectResearch Project

Description

The broad objective of this proposal is to quantitatively evaluate in
dynamic terms the intrinsic propulsive performance of intestinal regions of
cats and to examine how this performance is controlled by interactions
among neural and myogenic subsystems intrinsic to the intestine, the fluid
load being propelled and extrinsic control systems. The areas of
particular interest are: a) fluid propelling capability of intestinal
segments into an attached evaluation system having negligible resistance
and constant capacitance, b) fluid propelling capability into an evaluation
system having significant input resistance and infinite capacitance, c)
propulsive behavior when conditions associated with the evaluation system
vary as functions of time, properties resulting from the propulsion
process, or both, d) the ability of hormone and extrinsic neural inputs to
modulate propulsive performance, e) alterations of propulsive states by
transmural stimulation, and f) interactions among intestinal wall motions,
muscle mechanics, and propulsive behavior. The general method of approach
will be to measure, in vitro, the amount of fluid propelled from the oral
and aboral ends of an intestinal segment into an attached propulsion
evaluation system which imposes on the segment well-defined physical
conditions and permits the amount of propulsive work done in propelling a
given fluid volume to be determined.
StatusFinished
Effective start/end date12/1/786/30/86

Funding

  • National Institutes of Health

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Propulsion
Fluids
Capacitance
Hormones
Muscle
Mechanics
Control systems

Keywords

  • Medicine(all)