1,2,4-trihydroxynaphthalene-2-O-β-D-glucopyranoside delays amyloid-β42 aggregation and reduces amyloid cytotoxicity

Zohra Dhouafli, Manuela Leri, Monica Bucciantini, Massimo Stefani, Hamza Gadhoumi, Borhane Mahjoub, Hichem Ben Jannet, Jérôme Guillard, Riadh Ksouri, Moufida Saidani Tounsi, Claudio Soto, El Akrem Hayouni

Research output: Contribution to journalArticle

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Abstract

Presently, misfolding and aggregation of amyloid-β42 (Aβ42) are considered early events in Alzheimer's disease (AD) pathogenesis. The use of natural products to inhibit the aggregation process and to protect cells from cytotoxicity of early aggregate grown at the onset of the aggregation path is one of the promising strategies against AD. Recently, we have purified a new powerful antioxidant and inhibitor of Aβ42 aggregation from the leaves of Lawsonia inermis. The new compound was identified as a new Lawsoniaside; 1,2,4-trihydroxynaphthalene-2-O-β-D-glucopyranoside (THNG). Herein, we show that THNG interferes with Aβ42 aggregation, inhibits its conformational change to a β-sheet-rich structure, decreases its polymerization into large fibrillar species, reduces oxidative stress, and aggregate cytotoxicity. These results indicate that THNG has great potential as a neuroprotective and therapeutic agent against AD.

LanguageEnglish
Pages272-280
Number of pages9
JournalBioFactors
Volume44
Issue number3
DOIs
StatePublished - May 1 2018

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Amyloid
Alzheimer Disease
Lawsonia Plant
Neuroprotective Agents
Biological Products
Polymerization
Oxidative Stress
Antioxidants
Therapeutics

Keywords

  • Alzheimer's disease
  • amyloid cytotoxicity
  • Aβ42 aggregation
  • natural polyphenols
  • THNG

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

Cite this

Dhouafli, Z., Leri, M., Bucciantini, M., Stefani, M., Gadhoumi, H., Mahjoub, B., ... Hayouni, E. A. (2018). 1,2,4-trihydroxynaphthalene-2-O-β-D-glucopyranoside delays amyloid-β42 aggregation and reduces amyloid cytotoxicity. BioFactors, 44(3), 272-280. https://doi.org/10.1002/biof.1422

1,2,4-trihydroxynaphthalene-2-O-β-D-glucopyranoside delays amyloid-β42 aggregation and reduces amyloid cytotoxicity. / Dhouafli, Zohra; Leri, Manuela; Bucciantini, Monica; Stefani, Massimo; Gadhoumi, Hamza; Mahjoub, Borhane; Ben Jannet, Hichem; Guillard, Jérôme; Ksouri, Riadh; Saidani Tounsi, Moufida; Soto, Claudio; Hayouni, El Akrem.

In: BioFactors, Vol. 44, No. 3, 01.05.2018, p. 272-280.

Research output: Contribution to journalArticle

Dhouafli, Z, Leri, M, Bucciantini, M, Stefani, M, Gadhoumi, H, Mahjoub, B, Ben Jannet, H, Guillard, J, Ksouri, R, Saidani Tounsi, M, Soto, C & Hayouni, EA 2018, '1,2,4-trihydroxynaphthalene-2-O-β-D-glucopyranoside delays amyloid-β42 aggregation and reduces amyloid cytotoxicity' BioFactors, vol. 44, no. 3, pp. 272-280. https://doi.org/10.1002/biof.1422
Dhouafli, Zohra ; Leri, Manuela ; Bucciantini, Monica ; Stefani, Massimo ; Gadhoumi, Hamza ; Mahjoub, Borhane ; Ben Jannet, Hichem ; Guillard, Jérôme ; Ksouri, Riadh ; Saidani Tounsi, Moufida ; Soto, Claudio ; Hayouni, El Akrem. / 1,2,4-trihydroxynaphthalene-2-O-β-D-glucopyranoside delays amyloid-β42 aggregation and reduces amyloid cytotoxicity. In: BioFactors. 2018 ; Vol. 44, No. 3. pp. 272-280.
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