A composite neurobehavioral test to evaluate acute functional deficits after cerebellar haemorrhage in rats

Devin W. McBride, Derek Nowrangi, Harpreet Kaur, Guangyong Wu, Lei Huang, Tim Lekic, Jiping Tang, John H. Zhang

Research output: Contribution to journalArticle

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Abstract

Cerebellar haemorrhage accounts for 5–10% of all intracerebral haemorrhages and leads to severe, long-lasting functional deficits. Currently, there is limited research on this stroke subtype, which may be due to the lack of a suitable composite neuroscoring system specific for cerebellar injury in rodents. The purpose of this study is to develop a comprehensive composite neuroscore test for cerebellar injury using a rat model of cerebellar haemorrhage. Sixty male Sprague-Dawley rats were subjected to either sham surgery or cerebellar haemorrhage. Twenty-four hours post-injury, neurological behaviour was evaluated using 17 cost-effective and easy-to-perform tests, and a composite neuroscore was developed. The composite neuroscore was then used to assess functional recovery over seven days after cerebellar haemorrhage. Differences in the composite neuroscore deficits for the mild and moderate cerebellar haemorrhage models were observed for up to five days post-ictus. Until now, a composite neuroscore for cerebellar injury was not available for rodent studies. Herein, using mild and moderate cerebellar haemorrhage rat models a composite neuroscore for cerebellar injury was developed and used to assess functional deficits after cerebellar haemorrhage. This composite neuroscore may also be useful for other cerebellar injury models.

LanguageEnglish
Pages433-446
Number of pages14
JournalJournal of Cerebral Blood Flow and Metabolism
Volume38
Issue number3
DOIs
StatePublished - Mar 1 2018

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Hemorrhage
Wounds and Injuries
Rodentia
Cerebral Hemorrhage
Sprague Dawley Rats
Stroke
Costs and Cost Analysis
Research

Keywords

  • Cerebellar haemorrhage
  • cerebellar injury
  • composite neuroscore
  • neurobehaviour
  • stroke

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

A composite neurobehavioral test to evaluate acute functional deficits after cerebellar haemorrhage in rats. / McBride, Devin W.; Nowrangi, Derek; Kaur, Harpreet; Wu, Guangyong; Huang, Lei; Lekic, Tim; Tang, Jiping; Zhang, John H.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 38, No. 3, 01.03.2018, p. 433-446.

Research output: Contribution to journalArticle

McBride, Devin W. ; Nowrangi, Derek ; Kaur, Harpreet ; Wu, Guangyong ; Huang, Lei ; Lekic, Tim ; Tang, Jiping ; Zhang, John H. / A composite neurobehavioral test to evaluate acute functional deficits after cerebellar haemorrhage in rats. In: Journal of Cerebral Blood Flow and Metabolism. 2018 ; Vol. 38, No. 3. pp. 433-446.
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