A cross-sectional study investigating frequency and features of definitely diagnosed diabetic painful polyneuropathy

Andrea Truini, Vincenza Spallone, Roberto Morganti, Stefano Tamburin, Giampietro Zanette, Angelo Schenone, Chiara De Michelis, Valeria Tugnoli, Valentina Simioni, Fiore Manganelli, Raffaele Dubbioso, Giuseppe Lauria, Raffaella Lombardi, Stefano Jann, Luisa De Toni Franceschini, Solomon Tesfaye, Marco Fiorelli, Alessandra Spagnoli, Giorgio Cruccu

Research output: Contribution to journalArticle

Abstract

This cross-sectional multicentre study aimed at investigating frequency and features of painful diabetic polyneuropathy. We consecutively enrolled 816 patients attending hospital diabetic outpatient clinics. We first definitely diagnosed diabetic polyneuropathy and pure small-fibre polyneuropathy using clinical examination, nerve conduction study, and skin biopsy or quantitative sensory testing. Adhering to widely agreed criteria, we then identified neuropathic pain and diagnosed painful polyneuropathy using a combined approach of clinical examination and diagnostic tests. Of the 816 patients, 36% had a diabetic polyneuropathy associated with male sex, age, and diabetes severity; 2.5% of patients had a pure small-fibre polyneuropathy, unrelated to demographic variables and diabetes severity. Of the 816 patients, 115 (13%) suffered from a painful polyneuropathy, with female sex as the only risk factor for suffering from painful polyneuropathy. In this large study, providing a definite diagnosis of diabetic polyneuropathy and pure small-fibre polyneuropathy, we show the frequency of painful polyneuropathy and demonstrate that this difficult-to-treat complication is more common in women than in men.

LanguageEnglish
Pages2658-2666
Number of pages9
JournalPain
Volume159
Issue number12
DOIs
StatePublished - Dec 1 2018

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Polyneuropathies
Diabetic Neuropathies
Cross-Sectional Studies
Hospital Outpatient Clinics
Neural Conduction
Neuralgia
Routine Diagnostic Tests
Multicenter Studies
Demography
Biopsy
Skin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Truini, A., Spallone, V., Morganti, R., Tamburin, S., Zanette, G., Schenone, A., ... Cruccu, G. (2018). A cross-sectional study investigating frequency and features of definitely diagnosed diabetic painful polyneuropathy. Pain, 159(12), 2658-2666. https://doi.org/10.1097/j.pain.0000000000001378

A cross-sectional study investigating frequency and features of definitely diagnosed diabetic painful polyneuropathy. / Truini, Andrea; Spallone, Vincenza; Morganti, Roberto; Tamburin, Stefano; Zanette, Giampietro; Schenone, Angelo; De Michelis, Chiara; Tugnoli, Valeria; Simioni, Valentina; Manganelli, Fiore; Dubbioso, Raffaele; Lauria, Giuseppe; Lombardi, Raffaella; Jann, Stefano; De Toni Franceschini, Luisa; Tesfaye, Solomon; Fiorelli, Marco; Spagnoli, Alessandra; Cruccu, Giorgio.

In: Pain, Vol. 159, No. 12, 01.12.2018, p. 2658-2666.

Research output: Contribution to journalArticle

Truini, A, Spallone, V, Morganti, R, Tamburin, S, Zanette, G, Schenone, A, De Michelis, C, Tugnoli, V, Simioni, V, Manganelli, F, Dubbioso, R, Lauria, G, Lombardi, R, Jann, S, De Toni Franceschini, L, Tesfaye, S, Fiorelli, M, Spagnoli, A & Cruccu, G 2018, 'A cross-sectional study investigating frequency and features of definitely diagnosed diabetic painful polyneuropathy' Pain, vol. 159, no. 12, pp. 2658-2666. https://doi.org/10.1097/j.pain.0000000000001378
Truini, Andrea ; Spallone, Vincenza ; Morganti, Roberto ; Tamburin, Stefano ; Zanette, Giampietro ; Schenone, Angelo ; De Michelis, Chiara ; Tugnoli, Valeria ; Simioni, Valentina ; Manganelli, Fiore ; Dubbioso, Raffaele ; Lauria, Giuseppe ; Lombardi, Raffaella ; Jann, Stefano ; De Toni Franceschini, Luisa ; Tesfaye, Solomon ; Fiorelli, Marco ; Spagnoli, Alessandra ; Cruccu, Giorgio. / A cross-sectional study investigating frequency and features of definitely diagnosed diabetic painful polyneuropathy. In: Pain. 2018 ; Vol. 159, No. 12. pp. 2658-2666.
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