Accuracy of 5 Point-of-Care Glucometers in C57BL/6J Mice

Linnea A. Morley, Thomas H Gomez, Julia L. Goldman, Rene Flores, Mary A Robinson

Research output: Contribution to journalArticle

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Abstract

Despite few published studies that assess the accuracy of glucometers in laboratory animals, glucometers are commonly used in animal research. We set out to determine the accuracy of 5 point-of-care glucometers (POCG) when used to evaluate murine whole blood, plasma, and serum samples. The POCG tested included one veterinary device (POCG A) and 4 humanuse instruments (POCG B through E). Whole blood, plasma, and serum samples from 50 female C57BL/6J mice were analyzed on all POCG, and serum was analyzed on a reference biochemical analyzer. The mean blood glucose concentration (BGC) measured in whole blood by using POCG A was greater than that on the biochemical analyzer, whereas the mean BGC in whole blood according to POCG B through E did not differ significantly from that on the biochemical analyzer. Mean BGC in plasma and serum did not differ between POCG B and E and the biochemical analyzer, whereas the plasma and serum BGC values from POCG C and D were greater than the mean BGC from the biochemical analyzer. The accuracy of each POCG for each sample type was evaluated by analyzing mean differences, correlations, and Bland-Altman graphs. We found that the 4 human-use POCG are appropriate for use with whole blood from female C57BL/6J mice, whereas only 2 of the evaluated POCG were sufficiently accurate for use with plasma or serum.

LanguageEnglish
Pages44-50
Number of pages7
JournalJournal of the American Association for Laboratory Animal Science
Volume57
Issue number1
StatePublished - Jan 1 2018

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blood serum
blood glucose
mice
blood plasma
blood
animal research
sampling
laboratory animals

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Morley, L. A., Gomez, T. H., Goldman, J. L., Flores, R., & Robinson, M. A. (2018). Accuracy of 5 Point-of-Care Glucometers in C57BL/6J Mice. Journal of the American Association for Laboratory Animal Science, 57(1), 44-50.

Accuracy of 5 Point-of-Care Glucometers in C57BL/6J Mice. / Morley, Linnea A.; Gomez, Thomas H; Goldman, Julia L.; Flores, Rene; Robinson, Mary A.

In: Journal of the American Association for Laboratory Animal Science, Vol. 57, No. 1, 01.01.2018, p. 44-50.

Research output: Contribution to journalArticle

Morley, LA, Gomez, TH, Goldman, JL, Flores, R & Robinson, MA 2018, 'Accuracy of 5 Point-of-Care Glucometers in C57BL/6J Mice', Journal of the American Association for Laboratory Animal Science, vol. 57, no. 1, pp. 44-50.
Morley LA, Gomez TH, Goldman JL, Flores R, Robinson MA. Accuracy of 5 Point-of-Care Glucometers in C57BL/6J Mice. Journal of the American Association for Laboratory Animal Science. 2018 Jan 1;57(1):44-50.
Morley, Linnea A. ; Gomez, Thomas H ; Goldman, Julia L. ; Flores, Rene ; Robinson, Mary A. / Accuracy of 5 Point-of-Care Glucometers in C57BL/6J Mice. In: Journal of the American Association for Laboratory Animal Science. 2018 ; Vol. 57, No. 1. pp. 44-50.
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