Acquired versus congenital neonatal purpura fulminans: A case report and literature review

Tina Findley, Minal Patel, John Chapman, Deborah L Brown, Andrea F. Duncan

Research output: Contribution to journalReview article

Abstract

Neonatal purpura fulminans (PF) is a life-threatening disorder caused by congenital or acquired deficiencies of protein C (PC) or S. PF presents as a cutaneous manifestation of disseminated intravascular coagulation. We describe a case of PF in a newborn with left leg ischemia and undetectable PC levels soon after birth. Despite anticoagulation therapy and PC concentrate, left foot amputation was required. Genetic testing of PROC for congenital PC deficiency was normal. This case highlights the course of PF due to acquired PC deficiency in a newborn treated with PC concentrate which is rarely described in the literature.

LanguageEnglish
Pages625-627
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume40
Issue number8
DOIs
StatePublished - Nov 1 2018

Fingerprint

Purpura Fulminans
Protein C Deficiency
Protein C
Skin Manifestations
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Disseminated Intravascular Coagulation
Genetic Testing
Amputation
Foot
Leg
Ischemia
Parturition
Acquired Protein C Deficiency
Health

Keywords

  • Acquired protein C deficiency
  • Neonatal purpura fulminans
  • Protein C deficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Acquired versus congenital neonatal purpura fulminans : A case report and literature review. / Findley, Tina; Patel, Minal; Chapman, John; Brown, Deborah L; Duncan, Andrea F.

In: Journal of Pediatric Hematology/Oncology, Vol. 40, No. 8, 01.11.2018, p. 625-627.

Research output: Contribution to journalReview article

Findley, Tina ; Patel, Minal ; Chapman, John ; Brown, Deborah L ; Duncan, Andrea F. / Acquired versus congenital neonatal purpura fulminans : A case report and literature review. In: Journal of Pediatric Hematology/Oncology. 2018 ; Vol. 40, No. 8. pp. 625-627.
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