Acquisition, persistence, and clearance of human papillomavirus infection among male virgins residing in Brazil, Mexico, and the United States

Zhiyue Liu, Alan G. Nyitray, Lu Yu Hwang, Michael D. Swartz, Martha Abrahamsen, Eduardo Lazcano-Ponce, Luisa L. Villa, Anna R. Giuliano

Research output: Contribution to journalArticle

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Abstract

Background. Little is known about the natural history of human papillomavirus (HPV) infection in male virgins. This study estimated the incidence and clearance of genital HPV infection and the factors associated with these measures among men who denied at baseline ever having penetrative sex. Methods. A cohort of 4123 men residing in Brazil, Mexico, and the United States were followed every 6 months for up to 10 visits. Genital exfoliated cells were collected and genotyped for 36 HPV types. Eighty-seven men were classified as virgins and included for analysis. Cox proportional hazards models identified factors associated with the incidence and clearance of genital HPV infection. Results. The incidence rates for any HPV infection among virgins who did and those who did not initiate sex during follow-up were 26.2 and 14.6 cases/1000 person-months, respectively. After penetrative sex initiation, 45.5% of men acquired HPV within 24 months. Younger age, current smoking, no recent female sex partners, and prevalent HPV infection were associated with highrisk HPV clearance. Conclusion. Virgins who did not initiate sex during follow-up still acquired HPV infection, possibly through nonpenetrative sexual contact. Further prospective cohort studies are needed to better understand factors associated with HPV acquisition and clearance in male virgins and recent nonvirgins.

LanguageEnglish
Pages767-776
Number of pages10
JournalJournal of Infectious Diseases
Volume217
Issue number5
DOIs
StatePublished - Mar 1 2018

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Papillomavirus Infections
Mexico
Brazil
Cohort Studies
Incidence
Proportional Hazards Models
Smoking
Prospective Studies

Keywords

  • Clearance
  • Human papillomavirus
  • Incidence
  • Male
  • Persistence
  • Virgins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Acquisition, persistence, and clearance of human papillomavirus infection among male virgins residing in Brazil, Mexico, and the United States. / Liu, Zhiyue; Nyitray, Alan G.; Hwang, Lu Yu; Swartz, Michael D.; Abrahamsen, Martha; Lazcano-Ponce, Eduardo; Villa, Luisa L.; Giuliano, Anna R.

In: Journal of Infectious Diseases, Vol. 217, No. 5, 01.03.2018, p. 767-776.

Research output: Contribution to journalArticle

Liu, Z, Nyitray, AG, Hwang, LY, Swartz, MD, Abrahamsen, M, Lazcano-Ponce, E, Villa, LL & Giuliano, AR 2018, 'Acquisition, persistence, and clearance of human papillomavirus infection among male virgins residing in Brazil, Mexico, and the United States' Journal of Infectious Diseases, vol. 217, no. 5, pp. 767-776. https://doi.org/10.1093/infdis/jix588
Liu, Zhiyue ; Nyitray, Alan G. ; Hwang, Lu Yu ; Swartz, Michael D. ; Abrahamsen, Martha ; Lazcano-Ponce, Eduardo ; Villa, Luisa L. ; Giuliano, Anna R. / Acquisition, persistence, and clearance of human papillomavirus infection among male virgins residing in Brazil, Mexico, and the United States. In: Journal of Infectious Diseases. 2018 ; Vol. 217, No. 5. pp. 767-776.
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abstract = "Background. Little is known about the natural history of human papillomavirus (HPV) infection in male virgins. This study estimated the incidence and clearance of genital HPV infection and the factors associated with these measures among men who denied at baseline ever having penetrative sex. Methods. A cohort of 4123 men residing in Brazil, Mexico, and the United States were followed every 6 months for up to 10 visits. Genital exfoliated cells were collected and genotyped for 36 HPV types. Eighty-seven men were classified as virgins and included for analysis. Cox proportional hazards models identified factors associated with the incidence and clearance of genital HPV infection. Results. The incidence rates for any HPV infection among virgins who did and those who did not initiate sex during follow-up were 26.2 and 14.6 cases/1000 person-months, respectively. After penetrative sex initiation, 45.5{\%} of men acquired HPV within 24 months. Younger age, current smoking, no recent female sex partners, and prevalent HPV infection were associated with highrisk HPV clearance. Conclusion. Virgins who did not initiate sex during follow-up still acquired HPV infection, possibly through nonpenetrative sexual contact. Further prospective cohort studies are needed to better understand factors associated with HPV acquisition and clearance in male virgins and recent nonvirgins.",
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