Antepartum bleeding of unknown origin in the second half of pregnancy: A review

Everett F. Magann, Joseph E. Cummings, Amy Niederhauser, Diana Rodriguez-Thompson, Rebecca McCormack, Suneet P. Chauhan

Research output: Research - peer-reviewReview article

  • 14 Citations

Abstract

The objective of this study was to determine the prevalence, adverse pregnancy complications, and optimal management of pregnancies complicated by bleeding in the second half of pregnancy of an unknown origin (ABUO). A MEDLINE search from 1966 through November 2004 using the search terms "antepartum hemorrhage" or "hemorrhage" or "uterine hemorrhage" and "pregnancy complications" and "cardiovascular complications" and "second trimester pregnancy" or "third trimester pregnancy" was undertaken. The inclusion criteria focused on bleeding not: resulting from placenta previa or abruption or to any known cause. The MEDLINE search provided 24 abstracts for review with 9 studies meeting the inclusion criteria. The prevalence of ABUO was 2%. The likelihood of antepartum hemorrhage and delivery before 37 weeks was significant wuh an odds ratio (OR) of 3.17 and 95% confidence interval (CI) of 2.76-3.64. The risk of intrauterine fetal demise was significantly increased in women with ABUO (OR, 2.09; 95% Cl, 1.43-3.06). The association between ABUO and fetal anomalies was increased with an OR 1.42 (85% Cl, 1.07-1.87). Only one study with a small sample size P = 48) compared the outcomes of women using Doppler studies of the umbilical and uterine arteries and biophysical profiles. No differences were observed in the women undergoing antenatal testing and the women not undergoing antenatal testing. The prevalence of ABUO is 2%. Preterm delivery, stillbirth, and fetal anomalies appear to be increased in these pregnancies. Antenatal testing may be of limited value in their management.

LanguageEnglish
Pages741-745
Number of pages5
JournalObstetrical and Gynecological Survey
Volume60
Issue number11
DOIs
StatePublished - Nov 2005
Externally publishedYes

Fingerprint

Hemorrhage
Pregnancy
Odds Ratio
MEDLINE
Cardiovascular Pregnancy Complications
Placenta Previa
Uterine Artery
Umbilical Arteries
Fetal Death
Stillbirth
Pregnancy Complications
Uterine Hemorrhage
Third Pregnancy Trimester
Second Pregnancy Trimester
Sample Size
Confidence Intervals

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Magann, E. F., Cummings, J. E., Niederhauser, A., Rodriguez-Thompson, D., McCormack, R., & Chauhan, S. P. (2005). Antepartum bleeding of unknown origin in the second half of pregnancy: A review. Obstetrical and Gynecological Survey, 60(11), 741-745. DOI: 10.1097/01.ogx.0000182881.53139.f7

Antepartum bleeding of unknown origin in the second half of pregnancy : A review. / Magann, Everett F.; Cummings, Joseph E.; Niederhauser, Amy; Rodriguez-Thompson, Diana; McCormack, Rebecca; Chauhan, Suneet P.

In: Obstetrical and Gynecological Survey, Vol. 60, No. 11, 11.2005, p. 741-745.

Research output: Research - peer-reviewReview article

Magann, EF, Cummings, JE, Niederhauser, A, Rodriguez-Thompson, D, McCormack, R & Chauhan, SP 2005, 'Antepartum bleeding of unknown origin in the second half of pregnancy: A review' Obstetrical and Gynecological Survey, vol 60, no. 11, pp. 741-745. DOI: 10.1097/01.ogx.0000182881.53139.f7
Magann EF, Cummings JE, Niederhauser A, Rodriguez-Thompson D, McCormack R, Chauhan SP. Antepartum bleeding of unknown origin in the second half of pregnancy: A review. Obstetrical and Gynecological Survey. 2005 Nov;60(11):741-745. Available from, DOI: 10.1097/01.ogx.0000182881.53139.f7
Magann, Everett F. ; Cummings, Joseph E. ; Niederhauser, Amy ; Rodriguez-Thompson, Diana ; McCormack, Rebecca ; Chauhan, Suneet P./ Antepartum bleeding of unknown origin in the second half of pregnancy : A review. In: Obstetrical and Gynecological Survey. 2005 ; Vol. 60, No. 11. pp. 741-745
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