Biomarkers for bipolar disorder: current status and challenges ahead

Antonio L. Teixeira, Gabriela D. Colpo, Gabriel R. Fries, Isabelle E Bauer, Sudhakar Selvaraj

Research output: Contribution to journalReview article

Abstract

Introduction: Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and pathophysiological heterogeneity. There is a high expectation that personalized approaches can improve the management of patients with BD. For that, identification and validation of potential biomarkers are fundamental. Areas covered: This manuscript will critically review the current status of different biomarkers for BD, including peripheral, genetic, neuroimaging, and neurophysiological candidates, discussing the challenges to move the field forward. Expert commentary: There are no lab or complementary tests currently recommended for the diagnosis or management of patients with BD. Panels composed by multiple biomarkers will probably contribute to stratifying patients according to their clinical stage, therapeutic response, and prognosis.

LanguageEnglish
Pages67-81
Number of pages15
JournalExpert Review of Neurotherapeutics
Volume19
Issue number1
DOIs
StatePublished - Jan 2 2019

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Bipolar Disorder
Biomarkers
Neuroimaging
Psychiatry
Therapeutics

Keywords

  • biomarkers
  • Bipolar disorder
  • genetics
  • inflammation markers
  • neuroimaging
  • neurophysiological markers
  • oxidative stress markers
  • personalized psychiatry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Teixeira, A. L., Colpo, G. D., Fries, G. R., Bauer, I. E., & Selvaraj, S. (2019). Biomarkers for bipolar disorder: current status and challenges ahead. Expert Review of Neurotherapeutics, 19(1), 67-81. https://doi.org/10.1080/14737175.2019.1550361

Biomarkers for bipolar disorder : current status and challenges ahead. / Teixeira, Antonio L.; Colpo, Gabriela D.; Fries, Gabriel R.; Bauer, Isabelle E; Selvaraj, Sudhakar.

In: Expert Review of Neurotherapeutics, Vol. 19, No. 1, 02.01.2019, p. 67-81.

Research output: Contribution to journalReview article

Teixeira, AL, Colpo, GD, Fries, GR, Bauer, IE & Selvaraj, S 2019, 'Biomarkers for bipolar disorder: current status and challenges ahead', Expert Review of Neurotherapeutics, vol. 19, no. 1, pp. 67-81. https://doi.org/10.1080/14737175.2019.1550361
Teixeira, Antonio L. ; Colpo, Gabriela D. ; Fries, Gabriel R. ; Bauer, Isabelle E ; Selvaraj, Sudhakar. / Biomarkers for bipolar disorder : current status and challenges ahead. In: Expert Review of Neurotherapeutics. 2019 ; Vol. 19, No. 1. pp. 67-81.
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