Abstract
Introduction: Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and pathophysiological heterogeneity. There is a high expectation that personalized approaches can improve the management of patients with BD. For that, identification and validation of potential biomarkers are fundamental. Areas covered: This manuscript will critically review the current status of different biomarkers for BD, including peripheral, genetic, neuroimaging, and neurophysiological candidates, discussing the challenges to move the field forward. Expert commentary: There are no lab or complementary tests currently recommended for the diagnosis or management of patients with BD. Panels composed by multiple biomarkers will probably contribute to stratifying patients according to their clinical stage, therapeutic response, and prognosis.
| Language | English |
|---|---|
| Pages | 67-81 |
| Number of pages | 15 |
| Journal | Expert Review of Neurotherapeutics |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2 2019 |
Fingerprint
Keywords
- biomarkers
- Bipolar disorder
- genetics
- inflammation markers
- neuroimaging
- neurophysiological markers
- oxidative stress markers
- personalized psychiatry
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
- Pharmacology (medical)
Cite this
Biomarkers for bipolar disorder : current status and challenges ahead. / Teixeira, Antonio L.; Colpo, Gabriela D.; Fries, Gabriel R.; Bauer, Isabelle E; Selvaraj, Sudhakar.
In: Expert Review of Neurotherapeutics, Vol. 19, No. 1, 02.01.2019, p. 67-81.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Biomarkers for bipolar disorder
T2 - Expert Review of Neurotherapeutics
AU - Teixeira, Antonio L.
AU - Colpo, Gabriela D.
AU - Fries, Gabriel R.
AU - Bauer, Isabelle E
AU - Selvaraj, Sudhakar
PY - 2019/1/2
Y1 - 2019/1/2
N2 - Introduction: Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and pathophysiological heterogeneity. There is a high expectation that personalized approaches can improve the management of patients with BD. For that, identification and validation of potential biomarkers are fundamental. Areas covered: This manuscript will critically review the current status of different biomarkers for BD, including peripheral, genetic, neuroimaging, and neurophysiological candidates, discussing the challenges to move the field forward. Expert commentary: There are no lab or complementary tests currently recommended for the diagnosis or management of patients with BD. Panels composed by multiple biomarkers will probably contribute to stratifying patients according to their clinical stage, therapeutic response, and prognosis.
AB - Introduction: Bipolar disorder (BD) is a chronic psychiatric disorder marked by clinical and pathophysiological heterogeneity. There is a high expectation that personalized approaches can improve the management of patients with BD. For that, identification and validation of potential biomarkers are fundamental. Areas covered: This manuscript will critically review the current status of different biomarkers for BD, including peripheral, genetic, neuroimaging, and neurophysiological candidates, discussing the challenges to move the field forward. Expert commentary: There are no lab or complementary tests currently recommended for the diagnosis or management of patients with BD. Panels composed by multiple biomarkers will probably contribute to stratifying patients according to their clinical stage, therapeutic response, and prognosis.
KW - biomarkers
KW - Bipolar disorder
KW - genetics
KW - inflammation markers
KW - neuroimaging
KW - neurophysiological markers
KW - oxidative stress markers
KW - personalized psychiatry
UR - http://www.scopus.com/inward/record.url?scp=85059236324&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059236324&partnerID=8YFLogxK
U2 - 10.1080/14737175.2019.1550361
DO - 10.1080/14737175.2019.1550361
M3 - Review article
VL - 19
SP - 67
EP - 81
JO - Expert Review of Neurotherapeutics
JF - Expert Review of Neurotherapeutics
SN - 1473-7175
IS - 1
ER -