Caffeine intake is not associated with serum testosterone levels in adult men: cross-sectional findings from the NHANES 1999–2004 and 2011–2012

David S Lopez, Shailesh Advani, Xueting Qiu, Konstantinos K. Tsilidis, Mohit Khera, Jeri Kim, Steven Canfield

Research output: Contribution to journalArticle

Abstract

Objective: The association of caffeine intake with testosterone remains unclear. We evaluated the association of caffeine intake with serum testosterone among American men and determined whether this association varied by race/ethnicity and measurements of adiposity. Methods: Data were analyzed for 2581 men (≥20 years old) who participated in the cycles of the NHANES 1999–2004 and 2011–2012, a cross-sectional study. Testosterone (ng/mL) was measured by immunoassay among men who participated in the morning examination session. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable weighted linear regression models were conducted. Results: We identified no linear relationship between caffeine intake and testosterone levels in the total population, but there was a non-linear association (pnonlinearity <.01). Similarly, stratified analysis showed nonlinear associations among Mexican-American and Non-Hispanic White men (pnonlinearity ≤.03 both) and only among men with waist circumference <102 cm and body mass index <25 kg/m2 (pnonlinearity <.01, both). Conclusion: No linear association was identified between levels of caffeine intake and testosterone in US men, but we observed a non-linear association, including among racial/ethnic groups and measurements of adiposity in this cross-sectional study. These associations are warranted to be investigated in larger prospective studies.

LanguageEnglish
Pages45-54
Number of pages10
JournalAging Male
Volume22
Issue number1
DOIs
StatePublished - Jan 2 2019

Fingerprint

Nutrition Surveys
Caffeine
Testosterone
Serum
Adiposity
Linear Models
Cross-Sectional Studies
Waist Circumference
Immunoassay
Ethnic Groups
Body Mass Index
Prospective Studies
Population

Keywords

  • Caffeine intake
  • obesity
  • race/ethnicity
  • testosterone

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Caffeine intake is not associated with serum testosterone levels in adult men : cross-sectional findings from the NHANES 1999–2004 and 2011–2012. / Lopez, David S; Advani, Shailesh; Qiu, Xueting; Tsilidis, Konstantinos K.; Khera, Mohit; Kim, Jeri; Canfield, Steven.

In: Aging Male, Vol. 22, No. 1, 02.01.2019, p. 45-54.

Research output: Contribution to journalArticle

Lopez, David S ; Advani, Shailesh ; Qiu, Xueting ; Tsilidis, Konstantinos K. ; Khera, Mohit ; Kim, Jeri ; Canfield, Steven. / Caffeine intake is not associated with serum testosterone levels in adult men : cross-sectional findings from the NHANES 1999–2004 and 2011–2012. In: Aging Male. 2019 ; Vol. 22, No. 1. pp. 45-54.
@article{56ec27056ad7418cb09bbfa8cbb89926,
title = "Caffeine intake is not associated with serum testosterone levels in adult men: cross-sectional findings from the NHANES 1999–2004 and 2011–2012",
abstract = "Objective: The association of caffeine intake with testosterone remains unclear. We evaluated the association of caffeine intake with serum testosterone among American men and determined whether this association varied by race/ethnicity and measurements of adiposity. Methods: Data were analyzed for 2581 men (≥20 years old) who participated in the cycles of the NHANES 1999–2004 and 2011–2012, a cross-sectional study. Testosterone (ng/mL) was measured by immunoassay among men who participated in the morning examination session. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable weighted linear regression models were conducted. Results: We identified no linear relationship between caffeine intake and testosterone levels in the total population, but there was a non-linear association (pnonlinearity <.01). Similarly, stratified analysis showed nonlinear associations among Mexican-American and Non-Hispanic White men (pnonlinearity ≤.03 both) and only among men with waist circumference <102 cm and body mass index <25 kg/m2 (pnonlinearity <.01, both). Conclusion: No linear association was identified between levels of caffeine intake and testosterone in US men, but we observed a non-linear association, including among racial/ethnic groups and measurements of adiposity in this cross-sectional study. These associations are warranted to be investigated in larger prospective studies.",
keywords = "Caffeine intake, obesity, race/ethnicity, testosterone",
author = "Lopez, {David S} and Shailesh Advani and Xueting Qiu and Tsilidis, {Konstantinos K.} and Mohit Khera and Jeri Kim and Steven Canfield",
year = "2019",
month = "1",
day = "2",
doi = "10.1080/13685538.2018.1465912",
language = "English",
volume = "22",
pages = "45--54",
journal = "Aging Male",
issn = "1368-5538",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Caffeine intake is not associated with serum testosterone levels in adult men

T2 - Aging Male

AU - Lopez, David S

AU - Advani, Shailesh

AU - Qiu, Xueting

AU - Tsilidis, Konstantinos K.

AU - Khera, Mohit

AU - Kim, Jeri

AU - Canfield, Steven

PY - 2019/1/2

Y1 - 2019/1/2

N2 - Objective: The association of caffeine intake with testosterone remains unclear. We evaluated the association of caffeine intake with serum testosterone among American men and determined whether this association varied by race/ethnicity and measurements of adiposity. Methods: Data were analyzed for 2581 men (≥20 years old) who participated in the cycles of the NHANES 1999–2004 and 2011–2012, a cross-sectional study. Testosterone (ng/mL) was measured by immunoassay among men who participated in the morning examination session. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable weighted linear regression models were conducted. Results: We identified no linear relationship between caffeine intake and testosterone levels in the total population, but there was a non-linear association (pnonlinearity <.01). Similarly, stratified analysis showed nonlinear associations among Mexican-American and Non-Hispanic White men (pnonlinearity ≤.03 both) and only among men with waist circumference <102 cm and body mass index <25 kg/m2 (pnonlinearity <.01, both). Conclusion: No linear association was identified between levels of caffeine intake and testosterone in US men, but we observed a non-linear association, including among racial/ethnic groups and measurements of adiposity in this cross-sectional study. These associations are warranted to be investigated in larger prospective studies.

AB - Objective: The association of caffeine intake with testosterone remains unclear. We evaluated the association of caffeine intake with serum testosterone among American men and determined whether this association varied by race/ethnicity and measurements of adiposity. Methods: Data were analyzed for 2581 men (≥20 years old) who participated in the cycles of the NHANES 1999–2004 and 2011–2012, a cross-sectional study. Testosterone (ng/mL) was measured by immunoassay among men who participated in the morning examination session. We analyzed 24-h dietary recall data to estimate caffeine intake (mg/day). Multivariable weighted linear regression models were conducted. Results: We identified no linear relationship between caffeine intake and testosterone levels in the total population, but there was a non-linear association (pnonlinearity <.01). Similarly, stratified analysis showed nonlinear associations among Mexican-American and Non-Hispanic White men (pnonlinearity ≤.03 both) and only among men with waist circumference <102 cm and body mass index <25 kg/m2 (pnonlinearity <.01, both). Conclusion: No linear association was identified between levels of caffeine intake and testosterone in US men, but we observed a non-linear association, including among racial/ethnic groups and measurements of adiposity in this cross-sectional study. These associations are warranted to be investigated in larger prospective studies.

KW - Caffeine intake

KW - obesity

KW - race/ethnicity

KW - testosterone

UR - http://www.scopus.com/inward/record.url?scp=85060121047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060121047&partnerID=8YFLogxK

U2 - 10.1080/13685538.2018.1465912

DO - 10.1080/13685538.2018.1465912

M3 - Article

VL - 22

SP - 45

EP - 54

JO - Aging Male

JF - Aging Male

SN - 1368-5538

IS - 1

ER -