Correlates of childhood trauma in children and adolescents with bipolar disorder spectrum: A preliminary study

Fadwa Cazala, Isabelle E Bauer, Thomas D Meyer, Danielle E. Spiker, Iram F. Kazimi, Cristian P Zeni, Giovana Zunta Soares, Jair C Soares

Research output: Contribution to journalArticle

Abstract

Objective: Histories of childhood trauma (CT) are risk factors for affect dysregulation and poor clinical outcomes in women with bipolar disorder (BD). While much is known about the link between BD and CT in adult patients, there is limited data on this research topic in pediatric BD (PBD). The present study aims to investigate the impact of CT on irritability, aggressive and suicidal behaviors in PBD patients across gender types. Methods: From 2013 to 2015, 59 PBD patients Aged 6–17 (30 female) were administered the Childhood Trauma Questionnaire (CTQ) along with scales assessing irritability (Affective Reactivity Index), aggression (Modified Overt Aggression Scale) and suicidal thoughts and behaviors (Columbia-Suicide Severity Rating Scale). We examined the severity of these behaviors across types of CT and gender using univariate regression analyses. Findings were adjusted for age, number of traumas, and CTQ denial score. Results: In PBD patients, analyses showed that the effect of physical abuse depended on gender, whereby females were more likely than males to engage in suicidal thoughts and behaviors (p < 0.05). Male gender and CT were strong determinants of irritability (p < 0.05). Violence against property and people was found to be reduced in females, and increased in males with a history of emotional and sexual abuse, respectively (p < 0.05). Conclusion: These preliminary findings highlight the significant impact of CT in PBD and suggest that gender may predict the risk for dysfunctional behaviors in PBD patients with CT. Future large scale, longitudinal, investigations focusing on fear processing and extinction may provide a deeper understanding of these gender differences, and their role in the course of BD.

LanguageEnglish
Pages114-119
Number of pages6
JournalJournal of affective disorders
Volume247
DOIs
StatePublished - Mar 15 2019

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Bipolar Disorder
Wounds and Injuries
Pediatrics
Aggression
Sex Offenses
Risk-Taking
Violence
Suicide
Fear
Regression Analysis

Keywords

  • Bipolar disorder
  • Childhood trauma
  • Gender
  • Pediatric
  • Suicide
  • Violence

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Cazala, F., Bauer, I. E., Meyer, T. D., Spiker, D. E., Kazimi, I. F., Zeni, C. P., ... Soares, J. C. (2019). Correlates of childhood trauma in children and adolescents with bipolar disorder spectrum: A preliminary study. Journal of affective disorders, 247, 114-119. https://doi.org/10.1016/j.jad.2018.12.007

Correlates of childhood trauma in children and adolescents with bipolar disorder spectrum : A preliminary study. / Cazala, Fadwa; Bauer, Isabelle E; Meyer, Thomas D; Spiker, Danielle E.; Kazimi, Iram F.; Zeni, Cristian P; Zunta Soares, Giovana; Soares, Jair C.

In: Journal of affective disorders, Vol. 247, 15.03.2019, p. 114-119.

Research output: Contribution to journalArticle

Cazala, F, Bauer, IE, Meyer, TD, Spiker, DE, Kazimi, IF, Zeni, CP, Zunta Soares, G & Soares, JC 2019, 'Correlates of childhood trauma in children and adolescents with bipolar disorder spectrum: A preliminary study', Journal of affective disorders, vol. 247, pp. 114-119. https://doi.org/10.1016/j.jad.2018.12.007
Cazala, Fadwa ; Bauer, Isabelle E ; Meyer, Thomas D ; Spiker, Danielle E. ; Kazimi, Iram F. ; Zeni, Cristian P ; Zunta Soares, Giovana ; Soares, Jair C. / Correlates of childhood trauma in children and adolescents with bipolar disorder spectrum : A preliminary study. In: Journal of affective disorders. 2019 ; Vol. 247. pp. 114-119.
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