Levamisole-induced vasculitis

Tonya C George, Daniel J. Freet, James M Cross, Todd F Huzar

Research output: Contribution to journalArticle

Abstract

Levamisole is a veterinary antihelminthic, chemotherapeutic agent, and immunomodulator that also is used as an adulterant and cutting agent in cocaine distribution. This drug may potentiate the sympathomimetic actions of cocaine and can cause neutropenia, agranulocytosis, purpuric retiform lesions, and skin necrosis. This article describes two cases of suspected levamisole-induced vasculitis. No standardized diagnostic or treatment algorithm exists for this challenging condition. Diagnosis and treatment require a multidisciplinary team approach.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalJournal of the American Academy of Physician Assistants
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Levamisole
Vasculitis
Cocaine
Sympathomimetics
Agranulocytosis
Immunologic Factors
Neutropenia
Necrosis
Skin
Pharmaceutical Preparations

Keywords

  • ANCA vasculitis
  • cocaine vasculitis
  • cutaneous vasculopathy
  • levamisole
  • necrosis
  • retiform purpura

ASJC Scopus subject areas

  • Nurse Assisting

Cite this

Levamisole-induced vasculitis. / George, Tonya C; Freet, Daniel J.; Cross, James M; Huzar, Todd F.

In: Journal of the American Academy of Physician Assistants, Vol. 32, No. 1, 01.01.2019, p. 23-27.

Research output: Contribution to journalArticle

George, Tonya C ; Freet, Daniel J. ; Cross, James M ; Huzar, Todd F. / Levamisole-induced vasculitis. In: Journal of the American Academy of Physician Assistants. 2019 ; Vol. 32, No. 1. pp. 23-27.
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